Yongfeng Shang, Ph.D.


Yongfeng Shang, Ph.D.

Academician of Chinese Academy of Sciences


 

PhD: The Pennsylvania State University

Postdoctoral training: Dana-Farber Cancer Institute, Harvard Medical School


Contact:


Phone: 86-10-82805118 (O)

   86-10-82801397 (L)

Fax:  86-10-82801355

Email:
yshang@hsc.pku.edu.cn


Research Interest

  The researches in our lab are three-fold: 1) Molecular mechanisms involved in the tumorigenesis of breast cancer and endometrial cancer; 2) Epigenetic mechanisms for gene regulation; and 3) Molecular cloning and functional characterization of novel human genes. Over the years, our work have been published in journals such as Cell, Nature, Science, Nature Reviews Cancer, Genes & Development, PNAS, Molecular Cell, The EMBO Journal, EMBO reports, Molecular and Cellular Biology, Cancer Research, Journal of Biological Chemistry, Oncogene, etc.


Recent Publications (*Corresponding author)

 

1.    Fen Yang, Luyang Sun, Qian Li, Xiao Han, Liandi Lei, Hua Zhang*, and Yongfeng Shang* (2012). SET8 promotes epithelial-mesenchymal transition and confers Twist dual transcriptional activities. The EMBO Journal 31: 110-23 
2.    Xiaohan Yang, Wenhua Yu, Lei Shi, Luyang Sun, Jing Liang, Xia Yi, Qian Li, Yu Zhang, Fen Yang, Xiao Han, Di Zhang, Jie Yang, Zhi Yao, and Yongfeng Shang* (2011). HAT4, a Golgi Apparatus-anchored B-type Histone Acetyltransferase, Acetylates Free Histone H4 and Facilitates Chromatin Assembly. Molecular Cell 44: 39-50 
3.    Qian Li, Lei Shi, Bin Gui, Wenhua Yu, Jiamu Wang, Di Zhang, Xiao Han, Zhi Yao, and Yongfeng Shang* (2011). Binding of the JmjC demethylase JARID1B to LSD1/NuRD suppresses angiogenesis and metastasis in breast cancer cells by repressing chemokine CCL14. Cancer Research 71: 6899-908
4.  Lei Shi, Luyang Sun, Qian Li, Jing Liang, Wenhua Yu, Xia Yi, Xiaohan Yang, Yanyan Li, Xiao Han, Yu Zhang, Chenghao Xuan, Zhi Yao, and Yongfeng Shang* (2011). Histone demethylase JMJD2B coordinates H3K4/H3K9 methylation and promotes hormonally responsive breast carcinogenesis. Proc Natl Acad Sci U S A. 108: 7541-7546
5.  Yanyan Li, Luyang Sun, Yu Zhang, Dandan Wang, Feng Wang, Jing Liang, Bin Gui, and Yongfeng Shang* (2011). The histone modifications governing TFF1 transcription mediated by estrogen receptor The Journal of Biological Chemistry 286: 13925-13936
6.  Luyang Sun, Lei Shi, Feng Wang, Peiwei Huangyang, Wenzhe Si, Jie Yang, Zhi Yao*, and Yongfeng Shang* (2011). Substrate Phosphorylation and Feedback Regulation in JFK-promoted p53 Destabilization. The Journal of Biological Chemistry 286: 4226-4235
7.  Yu Zhang, Jing Liang, Yanyan Li, Chenghao Xuan, Feng Wang, Dandan Wang, Lei Shi, Di Zhang, and Yongfeng Shang* (2010). CCCTC-binding Factor Acts Upstream of FOXA1 and Demarcates the Genomic Response to Estrogen. The Journal of Biological Chemistry 285: 28604-28613
8.  Wenhua Yu, Ruifang Li, Bin Gui, and Yongfeng Shang* (2010). sZIP, an Alternative Splice Variant of ZIP, Antagonizes Transcription Repression and Growth Inhibition by ZIP. Journal of Biological Chemistry 285: 14301-14307
9.  Yan Wang, Hua Zhang, Yupeng Chen, Yimin Sun, Fen Yang, Wenhua Yu, Jing Liang, Luyang Sun, Xiaohan Yang, Lei Shi, Ruifang Li, Qian Li, Xia Yi, and Yongfeng Shang* (2009). LSD1 is a Subunit of the NuRD complex and Targets the Metastasis Programmes in Breast Cancer. Cell 138: 660-672
10. Luyang Sun, Lei Shi, Wenqian Li, Wenhua Yu, Jing Liang, Hua Zhang, Xiaohan Yang, Yan Wang, Ruifang Li, Xingrong Yao, Xia Yi, and Yongfeng Shang* (2009). JFK, a Kelch domain-containing F-box protein, links the SCF complex to p53 regulation. Proc Natl Acad Sci U S A. 106: 10195-10200
11.Ruifang Li, Hua Zhang, Wenhua Yu, Yupeng Chen, Bin Gui, Jing Liang, Yan Wang, Luyang Sun, Xiaohan Yang, Yu Zhang, Lei Shi, Yanyan Li, and Yongfeng Shang* (2009). ZIP: a Novel Transcription Repressor, Represses EGFR Oncogene and Suppresses Breast Carcinogenesis. The EMBO Journal 28: 2763-2776
12. Jing Liang, Hua Zhang, Yu Zhang, Ying Zhang, and Yongfeng Shang* (2009). GAS, a new glutamate-rich protein, interacts differentially with SRCs and is involved in oestrogen receptor function. EMBO reports 10: 51-57
13.  Yupeng Chen, Lei Shi, Lirong Zhang, Ruifang Li, Jing Liang, Wenhua Yu, Luyang Sun, Xiaohan Yang, Yan Wang, Yu Zhang, and Yongfeng Shang* (2008). The Molecular Mechanism Governing the Oncogenic Potential of SOX2 in Breast Cancer. Journal of Biological Chemistry 283: 17969-17978
14.  Dongwei Fan, Zhongqiang Chen*, Yupeng Chen, and Yongfeng Shang* (2007). Mechanistic Roles of Leptin in Osteogenic Stimulation in Thoracic Ligament Flavum Cells. Journal of Biological Chemistry 282: 29958-29966
15.  Xin Li, Jing Liang, Haijing Yu, Bing Su, Chunjie Xiao, Yongfeng Shang*, Wen Wang* (2007). Functional consequences of new exon acquisition in mammalian chromodomain Y-like (CDYL) genes. Trends in Genetics 23: 427-431
16.  Bin Shi1, Jing Liang1, Xiaohan Yang, Yan Wang, Youna Zhao, Huijian Wu, Luyang Sun, Ying Zhang, Yupeng Chen, Ruifang Li, Yu Zhang, Mei Hong, and Yongfeng Shang* (2007) . Integration of Estrogen and Wnt Signaling Circuits by the Polycomb Group Protein EZH2 in Breast Cancer Cells. Molecular and Cellular Biology 27: 5105-5119
17.Ying Zhang, Hua Zhang, Jing Liang, Wenhua Yu, and Yongfeng Shang* (2007). SIP, a novel ankyrin repeat containing protein, sequesters steroid receptor coactivators in the cytoplasm. The EMBO Journal 26: 2645-2657
18.    Shaosi Li, Yongfeng Shang* (2007). Regulation of SRC Family Coactivators by Post-translational Modifications. Cellular Signalling 19: 1101-1112 (invited review)
19.  Yongfeng Shang* (2007). Hormones and cancer. Cell Research 17: 277-279
20.  Hua Zhang, Luyang Sun, Jing Liang, Wenhua Yu, Ying Zhang, Yan Wang, Yupeng Chen, Ruifang Li, Xiaojing Sun, and Yongfeng Shang* (2006). The catalytic subunit of the proteasome is engaged in the entire process of estrogen receptor-regulated transcription. The EMBO Journal 25: 4223-4233
21.  Huijian Wu, Luyang Sun, Ying Zhang, Yupeng Chen, Bin Shi, Ruifang Li, Yan Wang, Jing Liang, Dongwei Fan, Ge Wu, Dan Wang, Shaosi Li, and Yongfeng Shang* (2006). Coordinated Regulation of AIB1 Transcriptional Activity by Sumoylation and Phosphorylation. Journal of Biological Chemistry 281: 21848-21856
22.  Yongfeng Shang* (2006). Molecular mechanisms of oestrogen and SERMs in endometrial carcinogenesis. Nature Reviews Cancer 6: 360-368 (invited review)
23.  Huijian Wu, Yupeng Chen, Jing Liang, Bin Shi, Ge Wu, Ying Zhang, Dan Wang, Ruifang Li, Xia Yi, Hua Zhang, Luyang Sun, and Yongfeng Shang* (2005). Hypomethylation-linked activation of PAX2 mediates tamoxifen-stimulated endometrial carcinogenesis. Nature 438: 981-987
24.  Hua Zhang, Xia Yi, Xiaojing Sun, Na Yin, Bin Shi, Huijian Wu, Dan Wang, Ge Wu, and Yongfeng Shang* (2004). Differential Gene Regulation by the SRC Family of Coactivators. Genes and Development 18: 1753-1765
25.  Na Yin, Dan Wang, Hua Zhang, Xia Yi, Xiaojing Sun, Bin Shi, Huijian Wu, Ge Wu, Xinjuan Wang, and Yongfeng Shang* (2004). Molecular Mechanisms Involved in the Growth Stimulation of Breast Cancer Cells by Leptin. Cancer Research 64: 5870-5875
26.   Xiaojing Sun, Hua Zhang, Dan Wang, Yan Shen*, and Yongfeng Shang* (2004). DLP, A Novel Dim1 Family Protein Implicated in Pre-mRNA Splicing and Cell Cycle Progression. Journal of Biological Chemistry 279: 32839-32847
27.   Ma Han, Yongfeng Shang, DY Lee, and Michael Stallcup (2003). Study of nuclear receptor-induced transcription complex assembly and histone modification by chromatin immunoprecipitation assays. Methods in Enzymology 364: 284-296
 
28.  Zebin Mao, Song Shan, Yunyan Zhu, Xia Yi, Hua Zhang, Yongfeng Shang*, and Tanjun Tong* (2003). Transcriptional Regulation of A33 Antigen Expression by Gut-enriched Krüppel-like Factor (GKLF). Oncogene 22: 4434-4443
29.  Yongfeng Shang and Myles Brown (2002). Molecular determinants for the tissue specificity of SERMs. Science 295: 2465-2468
30.  Yongfeng Shang, Molly Myers and Myles Brown (2002). The formation of androgen receptor transcription complex. Molecular Cell 9: 601-610
31.  Maricarmen D. Planas-Silva, Yongfeng Shang, Joana Liu Donaher, Myles Brown, and Robert A. Weinberg (2001). AIB1 enhances estrogen- dependent induction of cyclin D1 expression. Cancer Research 61: 3858-3862
32.  Yongfeng Shang, Xiao Hu, James Direnzo, Mitch Lazar, and Myles Brown (2000). Cofactor dynamics and sufficiency in estrogen receptor-regulated transcription. Cell 103: 843-852
33.  James DiRenzo, Yongfeng Shang, Michael Phelan, Said Sif, Molly Yancisin, Robert Kingston, and Myles Brown (2000). BRG-1 is recruited to estrogen-responsive promoters and cooperates with factors involved in histone acetylation. Molecular and Cellular Biology 20: 7541-7549
34.  Yongfeng Shang, Craig R. Baumrucker, and Michael H. Green (1999). Induction and activation of signal transducer and activator of transcription (STAT) 1 by all-trans-retinoic acid in breast cancer cells is mediated by RARb signaling pathways. Oncogene 18: 6725-6732
35.  Yongfeng Shang, Craig R. Baumrucker, and Michael H. Green (1999). Signal relay by RARa and RARb in retinoic acid-induced IGFBP3 expression in breast cancer cells. Journal of Biological Chemistry 274: 18005-18010 
36.  Yongfeng Shang, Craig R. Baumrucker, and Michael H. Green (1998). c-Myc is a major mediator of the synergistic growth inhibitory effects of retinoic acid and interferon in breast cancer cells. Journal of Biological Chemistry 273: 30608-30613 
 

Lab Members

 
 
   
 

Staff

 

 

 

Yongfeng Shang
Professor
Email:
yshang@hsc.pku.edu.cn

Jing Liang
Associate Professor
Email:
liang_jing@hsc.pku.edu.cn

 

Wenhua Yu
Associate Professor
Email:
yuwenhua@hsc.pku.edu.cn

Luyang Sun
Associate Professor
Email:
luyang_sun@hsc.pku.edu.cn

Xiaohan Yang
Lecturer
Email:
xiaohanyan@hsc.pku.edu.cn

Xia Yi
Lecturer
Email:
yixia@hsc.pku.edu.cn

Dan Wang
Senior Technician
Email:
wd@hsc.pku.edu.cn

Ge Wu
Assistant
Email:
wuge@hsc.pku.edu.cn


 

Postdoc

 

 

Yu Zhang
Ph.D. Student
Email: zhang_yu
@hsc.pku.edu.cn

 

Students

 

 

Xiao Han
Ph.D. Student
Email:
hanxiao@hsc.pku.edu.cn

Bin Gui
Ph.D. Student
Email:
bingui@hsc.pku.edu.cn

Dandan Wang
Ph.D. Student
Email:
wdd@hsc.pku.edu.cn

Feng Wang
Ph.D. Student
Email:
wangfeng@hsc.pku.edu.cn

 

 

Wenzhe Si
Ph.D. Student
Email:
wenzhesi@hsc.pku.edu.cn

Di Zhang
Ph.D. Student
Email:
zhangdi@hsc.pku.edu.cn

 

 

Ruorong Yan
Ph.D. Student
Email:
ruorongyan@hsc.pku.edu.cn

Zhe Chen
Ph.D. Student
Email:
zhechen@hsc.pku.edu.cn

 

 

Shumeng Liu
M.S. Student
Email:
shumeng@hsc.pku.edu.cn


 

Past Members

 

 

 

Huijian Wu
Postdoc

Bin Shi
Postdoc

 

   

Chenghao Xuan
Postdoc

Mei Hong
Postdoc

 

 

Xiaojing Sun
Ph.D.

Na Yin
M.S.

 

HuaZhang
Ph.D.

Ying Zhang
Ph.D.

 

 

Dongwei Fan
Ph.D.

Yupeng Chen
Ph.D.

 

 

Yan Wang
Ph.D.

Ruifang Li
Ph.D.

 

 

Qian Li
Ph.D.

Fen Yang
Ph.D.

 

 

Yanyan Li
Ph.D.

 

 

 

 

 

  

Photoes

 

Prof. Shang
Defense for PhD
Members of the lab photoed with Dr. Robert Weinberg

Prof. Shang

Lab Outing

 

  

 

 





 

Copyright © 2004, Department of Biochemistry and Molecular Biology
Peking University Health Science Center
Phone 86-10-82801144(L) 86-10-82802417(O)
Produced By 大汉网络 大汉版通发布系统